NITD-916 是一种 4-羟基-2-吡啶酮衍生物，是一种具有口服活性且高度亲脂性的分枝杆菌烯酰还原酶InhA抑制剂，IC50为 570 nM。NITD-916 与InhA和 NADH 形成三元复合物，以阻止进入脂肪酰基底物结合袋。NITD-916 具有有效的抗结核作用。

NITD-916, a 4-hydroxy-2-pyridone derivative, is an orally active and highly lipophilic mycobacterial enoyl reductase InhA inhibitor with an IC 50 of 570 nM. NITD-916 forms a ternary complex with InhA and NADH to block access to the fatty acyl substrate binding pocket. NITD-916 has potent anti-tuberculosis effects [1] [2].

1614262-83-7

C20H25NO2

311.42

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years