RMC-0331 (RM-023) is a potent, selective and orally bioavailable SOS1 inhibitor. RMC-0331 is an in vivo tool compound that blocks RAS activation via disruption of the RAS-SOS1 interaction[1].

RMC-0331 has an IC50 of 71 nM measuring by the rate of GDP/GTP exchange in vitro[1].

RMC-0331 (100-250 mg/kg; p.o.; qd; immunocompetent mice) shows single agent anti-tumor activity in SHP2-mutant models[1].

2488788-52-7

C22H25ClF3N5O3

499.92

RMC-0331

DMSO:125 mg/mL (250.05 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years