CSV0C018875 是一种基于喹啉的EHMT2/G9a抑制剂。 CSV0C018875 的细胞毒性低于 BIX-01294。

CSV0C018875 is a quinoline-based EHMT2/G9a inhibitor. CSV0C018875 exhibits lesser cytotoxicity than BIX-01294 [1].

CSV0C018875 (2.5-20 μM; 48 hours) inhibits the levels of H3K9me2 modifications in the histones [1]. Western Blot Analysis [1] Cell Line: HEK293 cells Concentration: 2.5 μM, 10 μM, 20 μM Incubation Time: 48 hours Result: Inhibited the enzymatic activity of G9a in a dose-dependent manner in HEK293 cells.

442150-41-6

C18H17ClN2O

312.79

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years