BRD7-IN-1 是一种修饰的 BI7273 衍生物 (BRD7/9 抑制剂)。BRD7-IN-1 通过与 VHL 配体连接形成PROTAC VZ185。VZ185 抑制 BRD7/9 的 DC50分别是 4.5 nM和1.8 nM。

BRD7-IN-1 is a modified derivative of BI7273 (BRD7/9 inhibitor) that binds to a VHL ligand via a linker to form a PROTAC VZ185 (VZ185 against BRD7/9 with DC 50 s of 4.5 and 1.8 nM, respectively) [1].

2448414-48-8

C22H28Cl2N4O3

467.39

BRD7-IN-1

DMSO:30 mg/mL (64.19 mM),Need ultrasonic
H2O:100 mg/mL (213.95 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years