The early stage of atherosclerosis is characterized by the aggregation of foam cells, so called a fatty streak, in the inner arterial wall. CAY10487 inhibits formation of fatty streak lesions of the thoracic aorta in high cholesterol-fed rabbits without affecting plasma lipid profiles or significantly inhibiting ACAT-1 or ACAT-2 activity. The percent area occupied by the atherosclerotic lesion in rabbits supplemented with 0.05% CAY10487 in the diet was 16.1% compared to 53.5% in control rabbits. CAY10487 also exhibits antioxidant activity, inhibiting copper-mediated oxidation of low-density lipoprotein by about 75% at a concentration of 2 μM.

778624-05-8

C13H15NO5

265.265

CAY10487

Ethanol:30 mg/mL
DMF:30 mg/mL
DMSO:30 mg/mL
Ethanol:PBS (pH 7.2) (1:5):0.35 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years