Teglarinad chloride (GMX-1777 and EB1627) is an effective NAMPT inhibitor. GMX1777 has potential antineoplastic activity. In vivo, GMX1777 is rapidly converted into GMX1778 through hydrolytic cleavage of a carbonate ester bond. GMX1778 appears to antagonize NF-kB transcription, resulting in the induction of tumor cell apoptosis.

432037-57-5

C30H43Cl2N5O8

672.6

EB1627;GMX1777;GMX-1777 chloride;GMX 1777;EB-1627;Teglarinad chloride

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years