(E)-5-(2-Bromovinyl)uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) that may be regenerated to BVDU in vivo. BVU irreversibly inactivates dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner. It enhances the efficacy of the chemotherapeutic agent and DPD substrate 5-fluorouracil in a P388 murine leukemia model when administered at a dose of 200 μmol/kg, increasing survival time.

69304-49-0

C6H5BrN2O2

217.02

(E)-5-(2-Bromovinyl)uracil

DMF:60 mg/mL
PBS (pH 7.2):8 mg/mL
Ethanol:0.8 mg/mL
DMSO:53 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years