COX-2-IN-24是一种有口服活性的COX-2抑制剂，IC50值为0.17 μM，表现出抗炎和低致溃疡活性。

COX-2-IN-24 is an orally active inhibitor of COX-2 with IC 50 value of 0.17 μM, shows anti-inflammatory and low ulcerogenic activities.

COX-2-IN-24 (Intraperitoneal injection; 9mg/100g; once an hour; 4 hours) shows anti-inflammatory activity in the carrageenan-induced rat paw edema model [1].COX-2-IN-24 (Oral gavage; 9mg/100g; once a day; 3 days) shows low ulcerogenic activity in the received 1% gum acacia (suspending vehicle) orally male albino rats model [1]. Animal Model: Mature male albino rats [1] Dosage: 9mg/100g Administration: Intraperitoneal injection; 9mg/100g; once an hour; 4 hours Result: Exhibited a promising anti-inflammatory activity in the carrageenan-induced rat paw edema model. Animal Model: Mature male albino rats [1] Dosage: 9mg/100g Administration: Oral gavage; 9mg/100g; once a day; 3 days Result: Exhibited low ulcerogenic activity in the received 1% gum acacia (suspending vehicle) orally male albino rats model.

2417995-10-7

C24H24BrN5O3S2

574.51

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years