7-Hydroxymethotrexate is a phase I metabolite of MTX, which is converted by hepatic aldehyde oxidases. 2 Formulations containing methotrexate have been used in the treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions. Elimination of 7-hydroxy MTX is associated with the multi-drug transporters Abcc2, Abcc3, and Abcg2 in transgenic mouse models.

5939-37-7

C20H22N8O6

470.44

7-羟基甲氨蝶呤;NSC 380962;NSC380962;NSC380963;NSC-380962;NSC 380963;NSC-380963;7-Hydroxymethotrexate

DMSO:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years