Nadifloxacin是一种对粉刺有效的广谱氟喹诺酮类抗生素。

Nadifloxacin has been used in trials studying the treatment of Acne Vulgaris.

Nadifloxacin is a potent, broad-spectrum, quinolone agent approved for topical use in acne vulgaris and skin infections. Nadifloxacin inhibits the enzyme DNA gyrase that is involved in bacterial DNA synthesis and replication, thus inhibiting the bacterial multiplication. In vitro studies of nadifloxacin show potent and broad-spectrum antibacterial activity against aerobic Gram-positive, Gram-negative and anaerobic bacteria. Additionally, studies also suggest that the effectiveness of nadifloxacin in inflammatory acne lesions may be attributed to its inhibitory effect on pro-inflammatory cytokines like interleukin (IL)-1α, IL-6, and IL-8 which also play an important role in acne pathogenesis.

124858-35-1

C19H21FN2O4

360.385

那氟沙星;OPC7251;Nadifloxacin

H2O:<1 mgml
DMSO:16 mg/mL (44.4 mM)
Ethanol:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years