p38 MAPK inhibitor IV is an ATP-competitive inhibitor of p38 MAP kinases with IC50 values of 0.13, 0.55, 5.47, and 8.63 μM for p38α, p38β, p38x, and p38δ, respectively, in vitro.[1] It also inhibits LPS-induced TNF-α and IL-1β cytokine production (IC50s = 22 and 44 nM, respectively) in human peripheral blood mononuclear cells.

1638-41-1

C12H4Cl6O4S

456.94

p38 MAPK Inhibitor IV;p38 MAP Kinase Inhibitor IV

DMF:2 mg/mL
DMSO:2.5 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years