MitoPBN is a mitochondria-targeted antioxidant. It accumulates in the mitochondria following the generation of a mitochondrial membrane potential by succinate, an effect that is blocked by addition of the mitochondrial membrane potential uncoupler FCCP . MitoPBN inhibits superoxide activation of mitochondrial uncoupling protein 1 (UCP1), UCP2, and UCP3 when used at a concentration of 250 nM in vitro but does not react with superoxide. It traps hydroxyl (IC50 = ~77 μM) and carbon-centered radicals and inhibits the initiation of lipid peroxidation in isolated bovine heart mitochondria.

652968-37-1

C33H37BrNO2P

590.542

MitoPBN

DMF:PBS(pH7.2) (1:2):0.33 mg/mL
DMSO:1 mg/mL
Ethanol:0.33 mg/mL
DMF:25 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years