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CMLD-2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CMLD-2图片
CAS NO:958843-91-9
包装:25 mg
市场价:11257元

产品介绍

产品描述

CMLD-2, an inhibitor of HuR-ARE interaction, competitively binds HuR protein disrupting its interaction with adenine-uridine rich elements (ARE)-containing mRNAs (Ki=350 nM). CMLD-2 induces apoptosis exhibits antitumor activity in different cancer cells as colon, pancreatic, thyroid and lung cancer cell lines. Hu antigen R (HuR) is an RNA binding protein, can regulate target mRNAs stability and translation[1][2].

体外活性

CMLD-2 (1-75 μM; 24-72 h) inhibits thyroid cancer cell viability[2].CMLD-2 (20-30 μM; 24-48 h) activates caspases and induces apoptotic cell death in H1299 and A549 cells[3].CMLD-2 (30 μM; 24-48 h) induces G1 cell cycle arrest and mitochondrial perturbation in H1299 and A549 cell[3].CMLD-2 (30 μM; 24-48 h) reduces expression of HuR and HuR-regulated mRNAs and proteins in H1299 cells[3].CMLD-2 (35 μM; 72 h) decreases directional migration capability in SW1736, 8505C, BCPAP and K1 cells. CMLD-2 induces a strong decrease of MAD2 mRNA levels in SW1736, 8505C, BCPAP and K1 cells[2]. Cell Viability Assay[2]Cell Line: SW1736, 8505C, BCPAP and K1 cells

Cas No.

958843-91-9

分子式

C31H31NO6

分子量

513.58

别名

CMLD-2

储存和溶解度

DMSO:50 mg/mL (97.36 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years