L-690330 is a competitive inositol monophosphatase inhibitor (Kis: 0.27 and 0.19 μM for recombinant human and bovine IMPase, 0.30 and 0.42 μM for human and bovine frontal cortex IMPase). L-690330 shows 10-fold more sensitive than a mouse and rat IMPase.

In HEK293 cells, L-690330 (50 μM; 1 hour) causes P-AMPK and autophagy and increases LC3-I/II and p-AMPK expression[2].

Except for a reduction in time spent in light in the dark/light test, L-690330 (intracerebroventricular?injection; 0.1 μmol) shows no effects on their motor activity and coordination in the beam walking [3].

142523-38-4

C8H12O8P2

298.12

L-690330

DMSO:25 mg/mL (83.86 mM),Need ultrasonic
H2O:33.33 mg/mL (111.80 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years