ATX inhibitor 5 is an orally active autotaxin (ATX) inhibitor (IC50: 15.3 nM). It has an anti-hepatofibrosis effect and reduces CCl4-induced hepatic fibrosis level prominently.

ATX inhibitor 5 displays anti-proliferative activities (IC50s: 1.21 and 0.78 μM).

ATX inhibitor 5 (20-40 mg/kg; p.o.; once daily for two weeks) reduces CCl4-induced hepatic fibrosis level prominently.

2402772-45-4

C22H18ClF3N6O

474.87

ATX inhibitor 5

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years