DHU-Se1 是一种有效的抗炎剂。DHU-Se1 可以刺激巨噬细胞释放活性硒化合物，降低细胞炎症因子 (如iNOS和TNF-α) 的表达。DHU-Se1 通过阻断巨噬细胞从 M0 到 M1 的极化来缓解炎症过程。

DHU-Se1 is a potent anti-inflammatory agent. DHU-Se1 can stimulate macrophages to release the reactive selenium compound and reduce the expression of cellular inflammatory factors (eg: iNOS and TNF-α ). DHU-Se1 alleviate the process of inflammation by blocking the polarization of macrophages from M0 to M1 [1].

DHU-Se1 (50 μM; 24 h) displays low biological toxicity in RAW cells [1]. DHU-Se1 (20 μM; 24 h) reduces the expression of cellular inflammatory factors [1]. DHU-Se1 (20 μM; 24 h) blocks the polarization of macrophages from M0 to M1 upon activation [1]. Cell Cytotoxicity Assay [1] Cell Line: RAW cells Concentration: 50 μM Incubation Time: 24 h Result: Displayed low biological toxicity with a survival rate larger than 80%. RT-PCR [1] Cell Line: RAW cells (co-treated with 100 ng/mL LPS) Concentration: 20 μM Incubation Time: 24 h Result: Reduced the expression of TNF-α and iNOS significantly. Western Blot Analysis [1] Cell Line: RAW 264.7 macrophages (co-treated with 100 ng/mL LPS) Concentration: 20 μM Incubation Time: 24 h Result: Significantly decreased the expression level of iNOS, indicating that M0 to M1 polarization was blocked. Released the reactive selenium compound.

C23H23N3OSSe

468.47

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years