5(S),6(R)-DiHETE is a dihydroxy polyunsaturated fatty acid and a nonenzymatic hydrolysis product of leukotriene A4 (LTA4). Mouse liver cytosolic epoxide hydrolase catalyzes the conversion of LTA4 to 5(S),6(R)-DiHETE. It is a weak LTD4 receptor agonist in guinea pig lung membranes. It induces guinea pig ileum contraction with an ED50 value of 1.3 μM.

82948-88-7

C20H32O4

336.47

5(S),6(R)-DiHETE

DMF:>50 mg/mL (per Rao Maddipati)
DMSO:>50 mg/mL (per Rao Maddipati)
PBS (pH 7.2):>1 mg/mL (from 13(S)-HODE)
Ethanol:>50 mg/mL (per Rao Maddipati)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years