ML291 是一种 UPR (未折叠蛋白反应)诱导的磺胺苯甲酰胺。ML291 在多种实体肿瘤模型中破坏 UPR 的适应能力，并在各种实体瘤模型中诱导细胞凋亡。ML291 可激活 UPR 的凋亡分支PERK/eIF2a/CHOP，减少白血病细胞负担。

ML291 is a UPR (unfolded protein response)-inducing sulfonamidebenzamide, that overwhelms the adaptive capacity of the UPR and induces apoptosis in a variety of solid cancer models. ML291 can activate the PERK/eIF2a/CHOP (apoptotic) arm of the UPR and reduce leukemic cell burden [1].

1523437-16-2

C16H16ClN3O6S

413.83

ML-291

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years