MCH-1 antagonist 1 also inhibits CYP3A4 (IC50: 10μM).MCH-1 antagonist 1 is a potent melanin concentrating hormone (MCH-1) antagonist (Ki: 2.6 nM).

MCH-1 antagonist 1 also inhibits cytochrome P450 3A4 (CYP3A4) (IC50:10 μM).

Effect of MCH-1 antagonist 1 (dosed at 30 mg/kg, po) is measured on the body weight of DIO mice with the AUC0-6 h of 14760 h*ng/mL.MCH-1 antagonist 1 is administered to male C57BL/6J DIO mice to assess their pharmacokinetic profile.

1039825-68-7

C25H26N4O2

414.5

MCH-1 antagonist 1

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years