(Rac)-Indoximod (1-Methyl-DL-tryptophan) 是吲哚胺-2,3-双加氧酶 (IDO) 抑制剂。(Rac)-Indoximod 和 IFN-γ 联用显著降低了表达 α-SMA 的人心肌成纤维细胞活性，并通过上调 IRF-1，Fas 和 FasL 基因诱导细胞凋亡，改善心肌纤维化。

(Rac)-Indoximod (1-Methyl-DL-tryptophan) is an indoleamine 2,3-dioxygenase ( IDO ) inhibitor. Co-treatment with IFN-γ and (Rac)-Indoximod markedly reduces the activity of human cardiac myofibroblasts (hCMs) expressing α-SMA and induces apoptosis through up-regulating the IRF-1, Fas, and FasL genes and ameliorates cardiac fibrosis[1].

(Rac)-Indoximod (1-Methyl-DL-tryptophan; 0.5 mM; 3 days) inhibits tryptophan depletion, thereby partially reversing the growth-inhibitory activity of IFN-γ, but eventually induces cell death irrespective of tryptophan depletion [1]. Cell Viability Assay [1] Cell Line: Human cardiac myofibroblasts (hCMs) Concentration: 0.5 mM Incubation Time: 3 days Result: Growth retardation by IFN-γ was partially reversed on day 2, but cell viability was further reduced on day 3.

26988-72-7

C12H14N2O2

218.256

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years