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Guanfacine-13C,15N3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Guanfacine-13C,15N3图片
CAS NO:1189924-28-4
包装:2 mg
市场价:8013元

产品介绍

产品描述

Guanfacine-13C,15N3is intended for us as an internal standard for the quantification of guanfacine by GC- or LC-MS. Guanfacine is an α2-adrenergic receptor (α2-AR) agonist with Kivalues of 93, 1,380, and 3,890 nM for α2A-, α2B-, and α2C-ARs, respectively, in a radioligand binding assay.1It has EC50values of 52, 288, and 602 nM for α2A-, α2B-, and α2C-ARs, respectively, for stimulated [35S]GTPγS binding. It also binds to imidazoline receptor 1 (Ki= 19 nM in a radioligand binding assay).2Guanfacine (0.3-5 mg/kg) binds to adrenergic receptors in the central nervous system and lowers blood pressure in hypertensive rats in a dose-dependent manner.3It also improves spatial working memory deficits induced by hypobaric hypoxia in rats.4Formulations containing guanfacine are used in the treatment of high blood pressure and attention deficit hyperactivity disorder (ADHD).

Cas No.

1189924-28-4

分子式

C9H9Cl2N3O

分子量

250.06

别名

Guanfacine-13C,15N3;Guanfacine-13C,15N3

储存和溶解度

Methanol:Slightly soluble,sonicated
Powder: -20°C for 3 years
In solvent: -80°C for 2 years