您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > 3-Hydroxykynurenine
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
3-Hydroxykynurenine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
3-Hydroxykynurenine图片
CAS NO:484-78-6
包装:10 mg
市场价:2520元

产品名称
DL-3-Hydroxykynurenine
3-hydroxy-DL-Kynurenine
产品介绍
3-Hydroxykynurenine 是色氨酸的活性代谢物,可抑制酵母和大鼠肝脏醛脱氢酶 97% 和 69%。

产品描述

3-Hydroxykynurenine is an active metabolite of tryptophan and inhibits yeast and rat liver aldehyde dehydrogenase by 97 and 69%.

体外活性

In CD3/CD28 bead-stimulated CD4+ T cells, 3-Hydroxykynurenine (0-100 μM) dose-dependently inhibits CD4+ T-cell proliferation (IC50 = 70 μM). 3-Hydroxykynurenine (0-100 μM) dose-dependently induces significant CD4+ T-cell-mediated cell[3].

体内活性

In BALB/c (H2d) mice, 3-Hydroxykynurenine (560 mg/kg; i.p.) significantly prolongs graft survival whether administered between days 1 to 7, days 7 to 14, or days 1 to 14[3].

Cas No.

484-78-6

分子式

C10H12N2O4

分子量

224.21

别名

DL-3-Hydroxykynurenine;3-hydroxy-DL-Kynurenine;3-Hydroxykynurenine

储存和溶解度

DMSO:1.4mg/mL (6mM),ultrasonic and warming and heat to 60°C
DMF:0.5 mg/mL
PBS (pH 7.2):0.5 mg/mL
Ethanol:2 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years