Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity. 14,15-EE-5(Z)-E is a structural analog of 14,15-epoxyeicosatrienoic acids (14,15-EET) that antagonizes EET-induced relaxation of vascular smooth muscle. Relaxation of U46619-constricted bovine arteries by 14,15-EET could be inhibited approximately 80% by 14,15-EE-5(Z)-E at a concentration of 10 μM. 14,15-EE-5(Z)-E does not appear to antagonize nitric oxide- or iloprost-mediated vascular relaxation.

519038-92-7

C20H36O3

324.5

14,15-EE-5(Z)-E

DMSO:10 mg/mL
DMF:10 mg/mL
PBS (pH 7.2):0.5 mg/mL
Ethanol:50 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years