NMS-859 是一种有效的含 valosin 蛋白 (VCP)/p97 的共价抑制剂，在细胞中存在 60 μM 和 1 mM ATP 的情况下，对野生型 VCP 的 IC50 分别为 0.37 μM 和 0.36 μM。

NMS-859 is an effective and covalent inhibitor of valosin-containing protein (VCP)/p97 with IC50s of 0.37 μM and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively.

NMS-859 suppresses the cell proliferation with IC50s of 3.0 μM and 3.5 μM in HeLa and HCT116 cell lines, respectively. NMS-859 shows weak inhibitory activity against VCPC522T[1].

1449236-96-7

C15H12ClN3O3S

349.79

ZINC169324353;NMS-859

DMSO:35 mg/mL (100.1 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years