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Rpn11-IN-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Rpn11-IN-1图片
CAS NO:2084867-65-0
包装:5 mg
市场价:7000元

产品名称
Capzimin intermediate
产品介绍

产品描述

Rpn11-IN-1 is an effective and selective inhibitor of proteasome subunit Rpn11 (IC50: 390 nM).

体内活性

Rpn11-IN-1 blocks the proliferation of tumor cells in culture. Rpn11 is a Zn2+-dependent metalloisopeptidase that hydrolyzes ubiquitin from tagged proteins that are trafficked to the proteasome for degradation. Rpn11-IN-1 has an IC50 of 2.1 μM and 3.8 μM against 293T and A549 cells, respectively. When inhibition of Rpn11-IN-1 against Rpn11 is measured in the presence of Zn(cyclen)2+ (100 μM), a significant loss in activity against Rpn11 is observed (IC50=77.4 μM vs. 0.39 μM). The observed IC50 value shift is attributed to the ability of Zn(cyclen)2+ to compete/titrate Rpn11-IN-1 away from Rpn11 [1].

Cas No.

2084867-65-0

分子式

C15H13N3OS2

分子量

315.41

别名

Capzimin intermediate;Rpn11-IN-1

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years