PSI-7409 is the active 5'-triphosphate metabolite of Sofosbuvir (PSI-7977).

The active triphosphate, PSI-7409, inhibited recombinant NS5B polymerases from genotypes 1 to 4 with comparable 50% inhibitory concentrations.?PSI-7409 also lacked any significant activity against cellular DNA and RNA polymerases.?No cytotoxicity, mitochondrial toxicity, or bone marrow toxicity was associated with PSI-7851 at the highest concentration tested (100 microM)[1].

1015073-42-3

C10H16FN2O14P3

500.16

PSI-7409

H2O:50 mg/mL (99.97 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years