CAY10784 is a STAT3 inhibitor (IC50= 0.74 μM in a reporter assay) and a derivative of WP1066 .1It inhibits proliferation of HeLa, Caco-2, A549, A375, U87MG, and HL-60 cancer cells (IC50s = 1.8, 1.8, 3, 2.8, 2.3, and 1.2 μM, respectively) but not PC3 or HT-29 cancer cells (IC50s = >10 μM for both). CAY10784 is also active againstH. pyloriandC. jejuni(MICs = 1.6 and 4.7 μM, respectively).2

1245814-52-1

C11H6F3N3O3S

317.24

CAY10784

DMF:30 mg/mL
DMSO:10 mg/mL
DMF:PBS (pH 7.2) (1:2):0.33 mg/mL
Ethanol:1 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years