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LY2606368 HCl(1234015-52-1 free base)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LY2606368 HCl(1234015-52-1 free base)图片
包装与价格:
包装价格(元)
5 mg电议
25 mg电议

产品名称
LY2606368 HCl
LY2606368 HCl (1234015-52-1 free base)
产品介绍

产品描述

LY2606368 HCl is a selective ATP competitive inhibitor of checkpoint kinase 1 (IC50: 1.5nM in SW1990 cells).

体外活性

LY2606368 HCl is an ATP-competitive inhibitor of CHK1 and is undergoing clinical trials currently. It inhibits the auto-phosphorylation of CHK1 and induces the phosphorylation of H2AX in cancer cells. In the pancreatic cell line SW1990, LY2606368 HCl significantly inhibits cell proliferation (IC50: 1.5nM). LY2606368 HCl also exerts potent anti-tumor activity in the SW1990 xenograft model. Besides that, in the orthotopic SKVO3 model, the treatment of LY2606368 HCl is found to inhibit tumor growth and reduce the incidence of metastases and accumulation. However, LY2606368 HCl is only administered intravenously due to its poor oral bioavailability [1][2][3].

Cas No.

T22957

分子式

C18H20ClN7O2

分子量

401.85

别名

LY2606368 HCl;LY2606368 HCl (1234015-52-1 free base)

储存和溶解度

DMSO:≥6.63mg/mL,with gentle warming
Powder: -20°C for 3 years
In solvent: -80°C for 2 years