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Calicheamicin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Calicheamicin图片
CAS NO:108212-75-5
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议

产品名称
卡奇霉素
Calicheamicin γ1
产品介绍
Calicheamicin 是肿瘤抗生素,可引起DNA双链断裂,抑制DNA合成。

产品描述

Calicheamicin is an antitumor antibiotic and is a DNA synthesis inhibitor. It also is a cytotoxic agent that causes double-strand DNA breaks.

体外活性

PF-06647263 (anti-EFNA4-ADC) is generated via conjugation of hE22 lysine residues to the AcButDMH-N-Ac-calicheamicin-γ1 linker-payload with an average drug-to-antibody ratio (DAR) of 4.6. PF-06647263 elicits antigen- and concentration-dependent cytotoxicity, as exposure to PF-06647263 for 96 hours results in cell death (EC50: ~1 ng/mL) [1].

体内活性

PF-06647263 (0.27, 0.36 mg/kg) results in significant tumor regressions in TNBC xenografts. An ADC comprising a humanized anti-EFNA4 monoclonal antibody conjugated to the DNA-damaging agent calicheamicin achieves sustained tumor regressions in both TNBC and ovarian cancer PDX in vivo [1].

Cas No.

108212-75-5

分子式

C55H74IN3O21S4

分子量

1368.35

别名

卡奇霉素;Calicheamicin γ1;Calicheamicin

储存和溶解度

DMSO:100 mg/mL (73.08 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years