MNK1/2-IN-6 是一种有效的选择性的MNK1/2抑制剂，IC50s 分别为 2.3 nM 和 3.4 nM。 MNK1/2-IN-6 以浓度依赖性方式诱导细胞凋亡Apoptosis。

MNK1/2-IN-6 is a potent and selective MNK1/2 inhibitor with IC 50 s of 2.3 nM and 3.4 nM for MNK1 and MNK2, respectively. MNK1/2-IN-6 induces apoptosis in a concentration-dependent manner [1].

MNK1/2-IN-6 (compound II-5) (72 h) shows antiproliferative activity with IC 50 s of 0.3896μM, 0.4092 μM for TMD-8, DOHH-2 cells, respectively [1]. MNK1/2-IN-6 (0.25, 0.5, 1 μM; 24 h) induces TMD-8 cells apoptosis in a concentration-dependent manner [1]. Cell Proliferation Assay [1] Cell Line: TMD-8, DOHH-2 cells Concentration: Incubation Time: 72 h Result: Showed antiproliferative activity with IC 50 s of 0.39μM, 0.41 μM for TMD-8, DOHH-2 cells, respectively. Apoptosis Analysis [1] Cell Line: TMD-8 cells Concentration: 0.25, 0.5, 1 μM Incubation Time: 24 h Result: Induced TMD-8 cells apoptosis in a concentration-dependent manner.

C27H24N6O

448.52

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years