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Talmapimod hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Talmapimod hydrochloride图片
CAS NO:309915-12-6
包装:5 mg
市场价:7000元

产品名称
SCIO-469 hydrochloride
产品介绍

产品描述

Talmapimod hydrochloride is a selective and ATP-competitive p38α inhibitor (IC50: 9 nM). It also shows about 10-fold selectivity over p38β, and at least 2000-fold selectivity over a panel of 20 other kinases, including other MAPKs.

体外活性

Talmapimod hydrochloride inhibits LPS-induced TNF-a production in human whole blood. Talmapimod hydrochloride decreases constitutive p38alpha MAPK phosphorylation of both 5T2MM and 5T33MM cells. Talmapimod hydrochloride (100-200 nM; 1 hour) inhibits phosphorylation of p38 MAPK in MM cells [1][2][3].

体内活性

Talmapimod hydrochloride (10-90 mg/kg; P.o.; twice daily orally for 14 days) dose-dependently reduced tumor growth. Talmapimod hydrochloride (10-90 mg/kg; P.o.; twice daily orally for 14 days) also dose-dependently reduced weight of the palpable tumors at termination [4].

Cas No.

309915-12-6

分子式

C27H31Cl2FN4O3

分子量

549.47

别名

SCIO-469 hydrochloride;Talmapimod hydrochloride

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years