SBI0206965 是一种强效,选择性和细胞渗透性自噬激酶ULK1抑制剂,对 ULK1 激酶活性的 IC50 为 108 nM,对 ULK2 的 IC50 为 711 nM。
产品描述
SBI-0206965 is a potent, selective and cell-permeable autophagy kinase ULK1 inhibitor with IC50 of 108 nM for ULK1 kinase activity and 711 nM for ULK2.
体外活性
In HEK293T transfected with WT or KI Myc-tagged ULK1 and WT Vps34, SBI-0206965 inhibits Ser249 phosphorylation of overexpressed Vps34 and Beclin1 Ser15 phosphorylation. SBI-0206965 suppresses autophagy induced by mTOR inhibition in A549 cells, and prevents ULK1-dependent cell survival in WT MEFs. In addition, SBI-0206965 also synergizes with mTOR inhibition to induce cancer cell death. [1]
Cas No.
1884220-36-3
分子式
C21H21BrN4O5
分子量
489.32
别名
SBI0206965;SBI-0206965
储存和溶解度
DMSO:20 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years