Calcimycin是抗生素和二价阳离子离子载体。它抑制革兰氏阳性细菌和一些真菌生长，也抑制 ATP 酶的活性并解耦哺乳动物细胞的氧化磷酸化。它通过增加细胞内钙浓度诱导 Ca2+依赖性细胞死亡。

Calcimycin is an ionophorous, polyether carboxylic antibiotic from Streptomyces chartreusensis. It binds and transports calcium and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria. The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.

Calcimycin mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner [4].

Calcimycin (2.5 or 7.5 nM; intrapleurally) induces protein leakage [5].

52665-69-7

C29H37N3O6

523.62

离子载体(钙镁盐混合物);Antibiotic A-23187;A-23187;Calcimycin

DMSO:47 mg/mL (89.76mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years