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ABT-107
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ABT-107图片
CAS NO:855291-54-2
包装与价格:
包装价格(元)
25 mg电议
50 mg电议
100 mg电议

产品介绍

产品描述

ABT-107 is a selective α7 neuronal nicotinic receptor agonist. ABT-107 protects against nigrostriatal damage in rats with unilateral 6-hydroxydopamine lesions.

体内活性

ABT-107 exhibits good bioavailability in mouse (orally, 51.1%; intraperitoneally,100%), rat (orally, 81.2%; intraperitoneally, 100.0%), and monkey (orally, 40.6%; intramuscularly, 100%), and good CNS penetration in rodents with a brain/plasma ratio of 1[1]. ABT-107 (0.01-1 μmol/kg i.p., 15 min before sacrifice) produces a dose-dependent increase in ERK1/2 and CREB[1]. ABT-107 (0.01, 0.1, and 1.0 mg/kg i.p.) increases S 9 -GSK3 and decreases p-tau in mouse cortex and hippocampus in mice[1]. ABT-107 (5 mg/kg/day i.p.) infusion attenuates tau hyperphosphorylation in AD transgenic APP-tau mice[1]. Animal Model: Rats (male Sprague-Dawley; 350-380 g b.wt.)[1]. Dosage: 1, 3 μmol/kg. Administration: I.P. daily for 3 consecutive days. Result: Induced a significant, dose-dependent increase in ACh release by day 3 of repeated administration. Higher doses may be required to evoke ACh release in naive rats not engaged in stimulated, i.e., cognitive-related behavior. Animal Model: Female TAPP (and wild-type littermates) mice[1]. Dosage: 1 mg/kg. Administration: Continuous subcutaneous infusion for 2 weeks. Result: Produced a dose-dependent increase in Ser9 phosphorylation in the cingulate cortex 15 min after acute administration in mice.

Cas No.

855291-54-2

分子式

C19H20N4O

分子量

320.39

别名

ABT-107

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years