DIF-3 通过激活GSK-3β促进其降解，从而降低 cyclin D1 和 c-Myc 的表达水平。DIF-3 抑制 DLD-1 细胞中的 Wnt/β-CATenin 信号通路相关蛋白。DIF-3通过诱导cyclin D1降解和抑制 cyclin D1 mRNA 表达对人宫颈癌细胞系HeLa发挥强大的抗增殖作用。

DIF-3 reduces the expression levels of cyclin D1 and c-Myc by facilitating their degradation via activation of GSK-3β. DIF-3 inhibits Wnt/β-catenin signaling pathway-related proteins in DLD-1 cells. DIF-3 exerts a strong antiproliferative effect on the human cervical cancer cell line HeLa by inducing cyclin D1 degradation and inhibiting cyclin D1 mRNA expression [1].

113411-17-9

C13H17ClO4

272.72

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years