您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > D8-MMAF
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
D8-MMAF
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
D8-MMAF图片
包装与价格:
包装价格(元)
100 mg电议
500 mg电议

产品名称
Monomethylauristatin F D8
产品介绍

产品描述

D8-MMAF is a microtubule destroyer, deuterated form of MMAF.

体外活性

MMAF showed cytotoxicity in vitro against a group of cell lines. Karpas 299, H3396, 786-O and Caki-1 have IC50 values of 119, 105, 257 and 200 nM, respectively. Targeted MMAF is more effective than free drug, and the cAC10 conjugate of MMAF shows significant activity. On a molar basis, the average potency of cAC10-L1-MMAF4 is more than 2200 times higher than free MMAF, and it is active in all tested CD30 positive cell lines.

体内活性

The maximum tolerated dose of MMAF (>16 mg / kg) mice is much higher than that of MMAE (1 mg / kg). The MTD of cAC10-L1-MMAF4 is 50 mg / kg in mice and 15 mg / kg in rats. The corresponding cAC10-L4-MMAF4 ADC is much less toxic, with MTD greater than 150 mg / kg and 90 mg / kg in mice and rats, respectively.

Cas No.

T10949

分子式

C39H57D8N5O8

分子量

740.01

别名

Monomethylauristatin F D8;D8-MMAF

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years