Mc-MMAE 是保护基团 (马来酰亚氨基己酰) 与 MMAE共轭连接得到的化合物。它是微管蛋白抑制剂，可用于偶联抗体。

Mc-MMAE is a drug-linker conjugate for ADC. Mc-MMAE is a maleimidocaproyl-conjugated monomethyl auristatin E, which is a potent tubulin inhibitor.

Synthesis of maleimidocaproyl-MMAE (mc-MMAE) requires the addition of maleimidocaproic acid to a solution of MMAE in dichloromethane followed by the addition of diethyl cyanophosphonate and diisopropylethylamine[1].

863971-24-8

C49H78N6O10

911.18

马来酰亚胺基己酰-单甲基澳瑞他汀 E;Maleimidocaproyl-monomethylauristatin E;Mc-MMAE

DMSO:51 mg/mL (55.97 mM)
H2O:< 0.1 mg/mL (insoluble),ultrasonic;warming;heat to 60°C
Powder: -20°C for 3 years
In solvent: -80°C for 2 years