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ML-9 Free Base
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ML-9 Free Base图片
CAS NO:110448-31-2
包装:5 mg
市场价:7000元

产品介绍

产品描述

ML-9 (free base) suppresses MLCK, PKA, and PKC activity (Ki: 4, 32, and 54 μM, respectively). ML-9 (free base) is a selective and effective inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK), and stromal interaction molecule 1 (STIM1) activity. ML-9 (free base) causes autophagy by stimulating autophagosome formation and inhibiting their degradation.

体外活性

ML9 (free base) (50?μM; 1-4?hours) obviously enhances cleaved caspase-3 levels, decreased STIM1 protein levels by about 42%. ML9 (free base) (0-100?μM; 0-24?hours) has no reduction in cardiomyocyte viability, 50-100?μM obviously causes cell death [2].

Cas No.

110448-31-2

分子式

C15H17ClN2O2S

分子量

324.83

别名

ML-9 Free Base

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years