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FTY720(S)-Phosphate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
FTY720(S)-Phosphate图片
CAS NO:402616-26-6
包装:5 mg
市场价:10767元

产品名称
(S)-FTY720P
(S)-FTY720 phosphate
FTY720 (S)-Phosphate
产品介绍

产品描述

FTY720 (S)-Phosphate is an S1P receptor 1 (S1PR1) agonist. It is used in the research of acute inflammatory diseases such as acute lung injury.

体外活性

FTY720 (S)-Phosphate (0.01-50 μM) also reduces β-arrestin recruitment to S1PR1. FTY720 (S)-Phosphate (Tys, 1 μM) maintains S1PR1 protein expression, enhances the human pulmonary artery endothelial cells barrier via S1PR1. But it shows no effect on inducing ubiquitination of S1PR1 [1].

体内活性

FTY720 (S)-Phosphate (0.5 mg/kg, i.p.) preserves S1PR1 expression in mouse lungs, is protective in bleomycin-induced acute lung injury (ALI). It attenuates lung tissue leukocyte infiltration in bleomycin-injured mice [1].

Cas No.

402616-26-6

分子式

C19H34NO5P

分子量

387.45

别名

(S)-FTY720P;(S)-FTY720 phosphate;FTY720 (S)-Phosphate

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years