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Mestranol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Mestranol图片
CAS NO:72-33-3
规格:≥98%
包装与价格:
包装价格(元)
50mg电议
100mg电议
250mg电议
500mg电议
1g电议
10g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)310.43
FormulaC21H26O2
CAS No.72-33-3
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 15 mg/mL (48.3 mM)
Water: <1 mg/mL
Ethanol: 25 mg/mL (80.5 mM)
Other info

Chemical Name: 17-ethynyl-3-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-ol

InChi Key: IMSSROKUHAOUJS-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H26O2/c1-4-21(22)12-10-19-18-7-5-14-13-15(23-3)6-8-16(14)17(18)9-11-20(19,21)2/h1,6,8,13,17-19,22H,5,7,9-12H2,2-3H3

SMILES Code: CC12CCC3C(C1CCC2(C#C)O)CCC4=C3C=CC(=C4)OC

Synonyms

Ethinyl Estradiol 3 Methyl Ether; Devocin; Norquen; Ovastol; Ethynylestradiol 3-methyl ether; Ethinyl Estradiol 3-Methyl Ether

实验参考方法
In Vitro

In vitro activity: Mestranol is extensively metabolized to hydroxylated products whose bio- logical activity is less well characterized.

In VivoMestranol (0.2 mg/kg) results in an increased percentage of liver occupied by AHF expressing glutathione S-transferase (PGST) in rats. Mestranol administration increases the focal hepatocyte labeling index compared with the control with a trend at the lower dose and a significant difference at the higher dose. Mestranol (0.02 mg/kg and 0.2 mg/kg diet) results in a decrease in the non-focal labeling index compared with that observed for the corresponding concentration of Mestranol alone. Mestranol significantly increases the non-focal hepatic labeling index in uninitiated rats compared with that observed in rats administered the basal diet only. Mestranol (50 mg/100 g b.wt.) has a significant reduction in the apparent number of alpha-2-adrenoceptors in the frontal cortex and nucleus tractus solitarius (NTS) of rat, while apparent numbers of both alpha-1 and alpha-2-adrenoceptors are depressed in the locus coeruleus.
Animal modelRats
Formulation & Dosage0.02 mg/kg and 0.2 mg/kg diet
References

Carcinogenesis. 1996 Sep;17(9):2043-52; Brain Res Bull. 1988 Aug;21(2):329-33.