Vutiglabridin (HSG4112) 是一种外消旋化合物，是一种有效的抗肥胖剂。Vutiglabridin 是光甘草定的优化结构类似物，在减重功效和化学稳定性方面具有优势。

Vutiglabridin (HSG4112), a racemic compound, is a potent anti-obesity agent [1]. Vutiglabridin, an optimized structural analog of Glabridin, markedly supersedes Glabridin in weight reduction efficacy and chemical stability [1].

Vutiglabridin (HSG4112) fully reverses adiposity in HFD-induced obese mice in a dose-dependent manner. Vutiglabridin (orally administered with 10, 30, or 100 mg/kg dose for 6 weeks) dose-dependently reduces body weight and normalizes obesity-related parameters in high-fat diet (HFD)-induced obese mice [2]. Animal Model: HFD-induced obese male C57BL/6J mice [2] Dosage: 10, 30, and 100 mg/kg Administration: Orally administered for 6 weeks Result: Led to significant dose-dependent body weight reduction by 4.0 g (8.3%), 10 g (21%), and 19 g (40%), respectively, compared to the 48.1 g body weight of HFD-induced obese mice administered with only the vehicle at 10, 30, and 100 mg/kg.

1800188-47-9

C22H26O4

354.44

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years