产品描述
The theoretical role of sigma receptors in psychosis has led to the discovery of selective sigma receptor ligands as potential antipsychotic agents. BMY 14802 is a sigma receptor ligand (IC50: 112 nM for (+)-[3H]-3-PPP).
体外活性
In vitro: BMY 14802 has its most potent binding at the sigma binding site, with some degree of serotonin subtype 1A and negligible dopamine receptor binding [1].
体内活性
In vivo: BMY 14802 is atypical of standard neuroleptics in that it does not induce catalepsy in rats. In addition, it has been shown to have efficacy in animal models of psychosis [1].
Cas No.
105565-55-7
分子式
C18H23ClF2N4O
分子量
384.85
别名
BMY 14802 hydrochloride;BMY-14802 hydrochloride
储存和溶解度
H2O:<9.62mg/ml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years