MSC2360844 是一种选择性的、具有口服活性的PI3Kδ抑制剂，其 IC50=145 nM。它对一组 278 种其他激酶显示出高度选择性。

MSC2360844 is a potent, orally active and selective inhibitor of PI3Kδ(IC50 of 145 nM).

MSC2360844 inhibits B cell proliferation in a concentration-dependent manner with an IC50 of 48?nM. MSC2360844 blocks BCR- and TCR-mediated responses in lymphocytes and TLR-induced IFNα by pDC in human primary cells[1].

in a murine SLE model，MSC2360844 ameliorates disease manifestations [1].

1305267-37-1

C26H27FN4O5S

526.58

MSC2360844

DMSO:90 mg/mL (170.91mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years