AZD3458 is a potent and remarkably selective inhibitor of PI3Kγ (PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ with pIC50s of 9.1, 5.1,<4.5, and 6.5 , respectively).

AZD3458 (Compound 15) is a potent and remarkably selective PI3Kγ inhibitor with ADME properties suitable for oral administration.?Compound 15 was advanced into in vivo studies showing dose-dependent inhibition of LPS-induced airway neutrophilia in rats when administered orally.

2132961-46-5

C20H23N3O4S2

433.54

AZD3458

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years