GSK2850163 hydrochloride 是一个新型的肌醇需要酶-1α (IRE1α) 抑制剂，它可抑制 IRE1α 的激酶活性和 RNA 酶活性，其IC50值分别为 20 和 200 nM。

GSK2850163 hydrochloride is a novel inhibitor of inositol-requiring enzyme-1 alpha ( IRE1α ) which can inhibit IRE1α kinase activity and RNase activity with IC 50 s of 20 and 200 nM, respectively.

GSK2850163 hydrochloride is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit IRE1α kinase activity and RNase activity with IC 50 s of 20 and 200 nM, respectively. The increased autophosphorylation of IRE1α can be reduced in a dose-dependent manner by GSK2850163 hydrochloride. Increasing concentrations of GSK2850163 hydrochloride are capable of reducing the increased XBP 1 transcriptional activity. Two additional kinases are weakly inhibited by GSK2850163 hydrochloride: Ron (IC 50 =4.4 μM) and FGFR1 V561M (IC 50 =17 μM) [1].

2319838-09-8

C24H30Cl3N3O

482.87

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years