CDK4/6-IN-7 是一种有效，选择性和具有口服活性的CDK4/6抑制剂，IC50值分别为 1.58 和 4.09 nM。CDK4/6-IN-7 可用于乳腺癌的研究。

CDK4/6-IN-7 is a potent, selective and orally active CDK4/6 inhibitor, with IC 50 s of 1.58 and 4.09 nM, respectively. CDK4/6-IN-7 can be used for the research of breast cancer [1].

CDK4/6-IN-7 (compound 7c) (0.1-656.1 μM; 48 h) inhibits the viability of MCF-7 cells, with an IC 50 of 0.92 μM [1]. Cell Proliferation Assay [1] Cell Line: MCF-7 cells Concentration: 0.1, 0.3, 0.9, 2.7, 8.1, 24.3, 72.9, 218.7, 656.1 μM Incubation Time: 48 hours Result: Inhibited MCF-7 cells growth, with an IC 50 of 0.92 μM.

CDK4/6-IN-7 (compound 7c) (50 mg/kg; p.o. once daily for 7d) strongly reduces tumor growth rates in MCF-7 tumor-bearing mice [1]. Animal Model: Female nude mice (5 weeks) bearing MCF-7 tumor [1] Dosage: 50 mg/kg Administration: Oral gavage once daily for 7 days Result: Inhibited tumor growth with the tumor inhibition rate of 57.68% and was well tolerated.

2649120-20-5

C18H18ClN5O3

387.82

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years