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Ulipristal(CDB-2914)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ulipristal(CDB-2914)图片
CAS NO:159811-51-5
规格:≥98%
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议
1g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)433.58
FormulaC28H35NO3
CAS No.159811-51-5
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 83 mg/mL (191.4 mM)
Water: <1 mg/mL
Ethanol: 14 mg/mL (32.3 mM)
Other info

Chemical Name: (8S,11R,13S,14S,17R)-17-acetyl-11-(4-(dimethylamino)phenyl)-13-methyl-3-oxo-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate

InChi Key: OOLLAFOLCSJHRE-ZHAKMVSLSA-N

InChi Code: InChI=1S/C30H37NO4/c1-18(32)30(35-19(2)33)15-14-27-25-12-8-21-16-23(34)11-13-24(21)28(25)26(17-29(27,30)3)20-6-9-22(10-7-20)31(4)5/h6-7,9-10,16,25-27H,8,11-15,17H2,1-5H3/t25-,26+,27-,29-,30-/m0/s1

SMILES Code: CC([C@@]1(OC(C)=O)CC[C@@]2([H])[C@]3([H])CCC4=CC(CCC4=C3[C@@H](C5=CC=C(N(C)C)C=C5)C[C@]12C)=O)=O

SynonymsCDB-2914; HRP2000, VA2914, RTI 3021-012, RU 44675, CDB2914, HRP 2000, VA-2914, CDB 2914, CDB-2914, CDB 2914, CDB2914, HRP-2000, VA 2914, Ulipristal acetate, EllaOne, Ella, Esmya
实验参考方法
In Vitro

In vitro activity: Ulipristal acetate has partial agonistic as well as antagonistic effects on the progesterone receptor. It also binds to theglucocorticoid receptor, but has no relevant affinity to the estrogen, androgen and mineralocorticoid receptors.

In VivoBased on clinical trials, ulipristal acetate seems to be a reasonably tolerable and effective method of emergency contraception when used within 120 hours of intercourse. Ulipristal acetate is at least as effective as LNG when used within the first 72 hours after unprotected intercourse. However, ulipristal acetate may be more effective than LNG when used between 72 to 120 hours after unprotected intercourse, extending the window of opportunity for emergency contraception.
Animal model
Formulation & Dosage
References

J Steroid Biochem Mol Biol. 2004 Mar;88(3):277-88; Clin Ther. 2012 Jan;34(1):24-36.