O-2050 是一种高亲和力的大麻素CB1受体拮抗剂，Ki为 2.5 nM。O-2050 抑制大麻素 CB2受体，Ki为 0.2 nM。O-2050 减少了小鼠的食物摄入量，并且引起小鼠运动。

O-2050 is a high affinity cannabinoid CB 1 receptor antagonist with a K i of 2.5 nM. O-2050 inhibits cannabinoid CB 2 receptor with Ki of 0.2 nM. O-2050 decreased food intake in mice and caused locomotor stimulation in mice [1].

O-2050 (1, 3, 10, 30 mg/kg; ip; pretreatment 30 mins) produces significant and dose-dependent decreases in food intake in mice. O-2050 (10, 30 mg/kg) markedly causes locomotor stimulation [1].

1883545-42-3

C23H31NO4S

417.56

O-2050

DMSO:<41.76mg/ml
Ethanol:<41.76mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years