MM 419447, a linaclotide metabolite, is a guanylate cyclase-C agonist. MM 419447 has the potential for the research of the irritable bowel syndrome with constipation (IBS-C).

MM 419447 exhibits high-affinity binding to T84 cells, resulting in a significant, concentration-dependent accumulation of intracellular cyclic guanosine-39,59-monophosphate (cGMP)[1].

MM 419447 (10 mg/kg; p.o.) treatment shows the C max , AUC 0-6 and t 1/2 values of 27 ng/mL, ≤ 29.7 ng h/mL and 0.33 hours, respectively[1]Animal Model: Female Sprague-Dawley rats[1]Dosage: 10 mg/kg Administration: P.o. (Pharmacokinetic Analysis) Result: The C max , AUC 0-6 and T max were 27 ng/mL, ≤ 29.7 ng h/mL and 0.33 hours, respectively.

1092457-78-7

C50H70N14O19S6

1363.55

MM 419447

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years