8(S)-HETE is a major lipoxygenase product in PMA-treated murine epidermis. It activates mouse keratinocyte protein kinase C with an IC50 of 100 μM. 8(S)-HETE also activates PPARα selectively at concentrations as low as 0.3 μM. Stereochemical assignment of the (S) enantiomer is based on comparison of chiral HPLC retention times to published results.

98462-03-4

C20H32O3

320.47

8(S)-HETE

Ethanol:Miscible
PBS (pH 7.2):0.8 mg/mL
DMF:Miscible
DMSO:Miscible
0.1 M Na2CO3:2 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years